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. 2021 Nov 29;11:750789. doi: 10.3389/fonc.2021.750789

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Copyright © 2021 Sin and Man

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The function of PRC2 complex in normal hemopoiesis. EZH2 mediates the methylation of lysine 27 of histone 3 tail (H3K27me3). The histone modification H3K27me3 recruits PRC1. CBX in PRC1 mediates mono-ubiquitylation of lysine 119 of histone 2A (H2AK119ub). Gene transcription is suppressed due to histone modification.