Table 6.

Example of genetic aberrations in ETP-ALL (18, 29, 30).

Gene	Type of aberration
Transcription factors
ETV6	Inactivating mutations/deletions
GATA3	Inactivating mutations/deletions
HOXA	Chromosomal rearrangements/inversions/overexpression
LMO2	Chromosomal rearrangement/deletions/overexpression
RUNX1	Inactivating mutations/deletions
WT1	Inactivating mutations/deletions
Signaling pathway
FLT3	Activating mutations/internal-tandem repeat
JAK1	Activating mutations
JAK3	Activating mutations
IL7R	Activating mutations
KRAS	Activating mutations
NRAS	Activating mutations
Epigenetic modifiers
DNMT3A	Inactivating mutations
EED	Inactivating mutations/deletions
EZH2	Inactivating mutations/deletions
PHF6	Inactivating mutations/deletions
SUZ12	Inactivating mutations/deletions
Genetic rearrangement
STIL-TAL1 fusion MEF2C rearrangement KMT2A rearrangement NUP98 rearrangement