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. 2021 Nov 24;24:11–19. doi: 10.1016/j.omtm.2021.11.008

Figure 2.

Figure 2

HLOs respond to VX compounds in a mutation-specific manner

(A) Quantification of swelling of cWT/cWT HLOs treated with VX-770 and/or VX-809. (B) Quantification of swelling of dF/dF HLOs treated with VX-770 and/or VX-809. (C) Quantification of swelling of dF/G551D HLOs treated with VX-770 and/or VX-809. Data are presented as mean ± standard error of the mean (SEM). n = 3 biological replicates for each condition (from three wells of organoids derived from independent differentiation processes). Unpaired t test (two tailed) was used to compare data using GraphPad Prism 8 (GraphPad Software).