Figure 4.

SGLT1/2 inhibitors promote CF HLO swelling

(A) Effects of PHL on the swelling of dF/dF HLOs derived from two CF patient-derived iPSC lines. (B) Effects of siRNA targeting SLC5A1 on the swelling of dF/dF HLOs. (C) Effects of PHL, Sota, and Empa on the swelling of dF/dF HLOs. In organoid swell assays, n = 3 biological replicates for each condition (from three wells of organoids derived from independent differentiation processes). Unpaired t test (two tailed) was used to compare data using GraphPad Prism 8 (GraphPad Software).