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. 2021 Nov 24;24:11–19. doi: 10.1016/j.omtm.2021.11.008

Figure 5.

Figure 5

Mechanistic insights into the effects of PHL and Sota on dF/dF HLO swelling

(A) Effects of GlyH-101 and PHL on the swelling of dF/dF HLOs. (B) Relative transcription levels of ANO1, AQP3, and AQP5 in cWT/cWT and dF/dF HLOs with or without Sota treatment. (C) Effects of siRNA targeting AQP5 on the swelling of dF/dF HLOs treated with Sota. n = 3 biological replicates for each condition (from three wells of organoids derived from independent differentiation processes). Unpaired t test (two tailed) was used to compare data using GraphPad Prism 8 (GraphPad Software).