Table 1.

Inclusion and exclusion criteria

Inclusion criteria	Exclusion criteria
Patient is 3–17 years of age	Indication for primary surgery
Patient presents with new-onset untreated CD according to the revised Porto criteria34	Symptomatic stenosis or stricture in the bowel due to scarring
wPCDAI >40 at baseline	Active perianal fistulas
Body weight >10 kg at baseline	Presence of a serious comorbidity, such as infection, sepsis, opportunistic infection, positive stool culture (Salmonella enterica, Shigella spp, Yersinia enterocolitica or Campylobacter spp), positive Clostridium difficile toxin assay or positive tuberculosis screening
	Presentation with suspected or definite pregnancy
	Already using CD-specific therapy

CD, Crohn’s disease; wPCDAI, weighted Paediatric Crohn’s Disease Activity Index.