Table 5.

Findings at week 52 per treatment group

	First-line IFX	Conventional	P value
wPCDAI, median (IQR)	7.5 (0–15)	10 (0–17.5)	0.476
Clinical remission, n (%)	33/47 (70)	26/46 (57)	0.420
Clinical remission in patients on immunomodulator monotherapy, n (%)	22/29 (76)	12/18 (67)	0.958
Endoscopic remission, n (%)*	5/18 (28)	5/14 (36)	0.630
SES-CD, median (IQR)	7 (2–7)	6 (0–10)	0.961
Fcal <100 µg/g, n (%)	17/48 (35)	9/47 (19)	0.120

Clinical remission is defined as a wPCDAI <12.5. Endoscopic remission was defined as a SES-CD <3. The group of patients on immunomodulator monotherapy comprised patients on azathioprine (n=46) and methotrexate (n=1). Baseline characteristics of these patients are similar (online supplemental table 2C).

*Eighteen FL-IFX patients and 14 conventionally treated patients consented for endoscopy at week 52.

Fcal, faecal calprotectin; IFX, infliximab; SES-CD, Simple Endoscopic Score for Crohn’s Disease; wPCDAI, weighted Paediatric Crohn’s Disease Activity Index.