Table 4.
Multivariable Cox Proportional Hazards Regression Models Assessing the Association of Each Incident Medical Condition with Baseline Demographic and Clinical Characteristics
| Baseline characteristic [HR (95% CI)a] | Oncologic |
Endocrine |
Respiratory |
Hematologic |
Cardiovascular |
||||
|---|---|---|---|---|---|---|---|---|---|
| Subsequent cancers | Disorders of calcium and phosphorus metabolism | Diabetes mellitus | Asthma | Other infectious/inflammatory respiratory diseases | Cytopenias | Leukocytosis | Hypertension | Diseases of the heart | |
| Sex | |||||||||
| Male | Reference | Reference | Reference | Reference | Refence | Reference | Reference | Reference | Reference |
| Female | 1.11 (0.81–1.52) | 1.17 (0.82–1.68) | 0.60 (0.45–0.82) | 2.22 (1.43–3.44) | 0.62 (0.44–0.87) | 1.65 (1.30–2.08) | 0.69 (0.42–1.15) | 0.66 (0.54–0.81) | 0.49 (0.38–0.65) |
| Age at diagnosis | |||||||||
| 15–29 | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| 30–34 | 1.79 (1.30–2.48) | 0.73 (0.52–1.03) | 1.53 (1.08–2.16) | 0.98 (0.73–1.33) | 1.12 (0.77–1.62) | 0.98 (0.81–1.17) | 2.47 (1.41–4.33) | 1.62 (1.27–2.06) | 1.30 (0.93–1.83) |
| 35–39 | 2.42 (1.79–3.27) | 0.99 (0.74–1.32) | 2.12 (1.55–2.91) | 1.01 (0.76–1.33) | 1.35 (0.96–1.90) | 0.98 (0.82–1.16) | 2.19 (1.27–3.77) | 2.83 (2.29–3.51) | 2.16 (1.61–2.90) |
| Race/ethnicity | |||||||||
| Non-Hispanic White | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| Hispanic | 1.06 (0.79–1.42) | 1.33 (0.99–1.79) | 1.65 (1.22–2.24) | 0.91 (0.69–1.22) | 0.83 (0.59–1.18) | 1.28 (1.07–1.52) | 1.06 (0.64–1.74) | 1.25 (1.02–1.53) | 1.06 (0.79–1.43) |
| Asian/Pacific Islander | 1.57 (1.16–2.11) | 0.93 (0.62–1.40) | 0.97 (0.62–1.50) | 0.38 (0.22–0.63) | 0.47 (0.26–0.83) | 1.06 (0.85–1.34) | 0.64 (0.30–1.36) | 1.05 (0.81–1.37) | 1.05 (0.72–1.52) |
| Black | 0.75 (0.34–1.65) | 0.70 (0.28–1.72) | 2.29 (1.30–4.03) | 1.56 (0.92–2.65) | 1.44 (0.74–2.78) | 1.57 (1.08–2.28) | 0.86 (0.26–2.90) | 2.02 (1.37–2.97) | 1.89 (1.09–3.27) |
| Other/unknown | 0.59 (0.14–2.44) | 1.32 (0.48–3.64) | 0.96 (0.28–3.23) | 0.24 (0.03–1.75) | 1.78 (0.69–4.55) | 1.70 (0.98–2.93) | 0.73 (0.09–5.68) | 1.27 (0.62–2.60) | 1.31 (0.48–3.55) |
| Year of diagnosis | |||||||||
| 1996–2000 | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| 2001–2004 | 1.08 (0.78–1.50) | 1.33 (0.95–1.87) | 0.9 (0.69–1.30) | 1.01 (0.74–1.38) | 1.17 (0.82–1.66) | 0.97 (0.80–1.19) | 1.60 (0.87–2.96) | 0.82 (0.66–1.01) | 0.87 (0.64–1.20) |
| 2005–2008 | 1.32 (0.89–1.96) | 1.83 (1.26–2.65) | 0.89 (0.61–1.29) | 1.31 (0.93–1.83) | 0.93 (0.60–1.44) | 1.15 (0.92–1.43) | 2.78 (1.49–5.18) | 0.80 (0.62–1.04) | 0.95 (0.67–1.37) |
| 2009–2012 | 1.61 (0.90–2.86) | 1.48 (0.90–2.44) | 1.01 (0.61–1.67) | 0.97 (0.60–1.57) | 0.71 (0.36–1.39) | 1.20 (0.89–1.64) | 1.95 (0.82–4.62) | 0.97 (0.67–1.41) | 0.60 (0.33–1.11) |
| Histology | |||||||||
| Follicular | 1.01 (0.66–1.55) | 0.89 (0.54–1.48) | 0.79 (0.48–1.30) | 1.19 (0.78–1.81) | 0.86 (0.50–1.49) | 0.98 (0.74–1.30) | 0.60 (0.24–1.54) | 1.07 (0.79–1.43) | 0.88 (0.55–1.39) |
| Papillary | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| Stage at diagnosis | |||||||||
| Localized/regional | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| Advanced | 1.14 (0.63–2.05) | 1.96 (1.18–3.26) | 1.13 (0.62–2.06) | 0.70 (0.33–1.49) | 1.87 (1.06–3.28) | 1.41 (1.00–1.98) | 1.40 (0.56–3.51) | 0.84 (0.53–1.33) | 0.94 (0.51–1.75) |
| Missing | 1.29 (0.54–3.12) | 2.49 (1.07–5.81) | 0.83 (0.26–2.60) | 1.22 (0.44–3.34) | 0.65 (0.16–2.69) | 0.79 (0.38–1.62) | 0.68 (0.09–5.07) | 0.77 (0.34–1.76) | 1.70 (0.74–3.93) |
| Neighborhood SES | |||||||||
| High | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| Low | 0.92 (0.73–1.18) | 1.26 (0.96–1.66) | 1.42 (1.07–1.89) | 1.41 (1.08–1.84) | 1.39 (1.01–1.92) | 1.23 (1.04–1.44) | 1.62 (0.97–2.68) | 1.15 (0.96–1.38) | 1.14 (0.88–1.49) |
| Health insurance | |||||||||
| Private/military | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| Public/none | 1.05 (0.72–1.53) | 1.64 (1.20–2.26) | 1.81 (1.32–2.48) | 1.57 (1.16–2.14) | 3.24 (2.33–4.51) | 1.48 (1.22–1.80) | 2.52 (1.51–4.18) | 1.78 (1.43–2.22) | 2.30 (1.70–3.10) |
| Unknown | 1.61 (0.80–3.24) | 0.67 (0.21–2.15) | 3.01 (1.70–5.34) | 0.70 (0.22–2.20) | 2.23 (0.95–5.22) | 1.31 (0.80–2.15) | 1.80 (0.52–6.25) | 1.63 (0.98–2.73) | 0.62 (0.20–1.92) |
| Initial treatment | |||||||||
| Total thyroidectomy plus radioiodine | 1.06 (0.78–1.43) | 1.49 (0.99–2.24) | 0.86 (0.62–1.18) | 1.09 (0.78–1.51) | 0.91 (0.62–1.34) | 1.14 (0.93–1.40) | 0.49 (0.29–0.83) | 0.99 (0.79–1.23) | 0.94 (0.68–1.28) |
| Total thyroidectomy without radioiodine | 0.95 (0.68–1.33) | 1.98 (1.30–3.02) | 0.96 (0.68–1.36) | 1.23 (0.86–1.75) | 1.05 (0.70–1.58) | 1.42 (1.14–1.77) | 1.00 (0.60–1.68) | 1.05 (0.83–1.34) | 0.95 (0.68–1.35) |
| Partial/no thyroidectomy | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| Neck reoperationb | |||||||||
| No | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| Yes | 1.11 (0.65–1.91) | 2.83 (1.93–4.14) | 1.76 (1.09–2.82) | 2.28 (1.51–3.45) | 1.79 (1.05–3.05) | 1.41 (1.05–1.89) | 1.58 (0.66–3.79) | 1.80 (1.29–2.52) | 1.73 (1.07–2.78) |
Incident medical conditions obtained from hospital discharge records.
a
Adjusted for all variables in the table and overweight/obesity and tobacco use disorder.
b
Neck reoperation was consider as time-dependent variable.
HR, hazard ratio.