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. 2021 Jan 27;71(1):78–87. doi: 10.1136/gutjnl-2020-323347

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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The alteration of gut microbiota was closely associated with the bile acid levels. (A) Pearson’s correlations of retinol and retinene levels with the levels of (a) CA, (b) LCA and TUDCA. Red indicates a positive correlation, and blue indicates a negative correlation. (B) Spearman’s correlation analysis of differential genus microbiota levels with CA, LCA and TUDCA levels. (C) Spearman’s correlation analysis of Ruminococcaceae_NK4A214_group abundance with (a) CA, (b) LCA and (c) TUDCA levels. CA, cholic acid; LCA, lithocholic acid; TUDCA, tauroursodeoxycholic acid.