TABLE 1.

Half-lives of β-globin Cox-2 reporter mRNAs in the presence of MKK6, dexamethasone, or SB203580^a

Transcript	Half-lifeb of transcript (h)
	Control	MKK6	MKK6+Dex	MKK6+SB
β-globin–Cox2.5	1.16	2.00	1.08	1.32
β-globin–Cox1.4	1.24	2.06	1.29	1.07
β-globin–Cox0.6	1.02	2.24	1.31	1.15
β-globin–Cox0.1	1.26	4.16	1.65	1.64
β-globin–Cox0.5	NMc	NM	NM	NM

^aTransfections, treatments, and RNase protection assays were essentially as described in the legend to Fig. 2. SB203580 (1 μM) was added 30 min prior to the addition of tetracycline, and dexamethasone (1 μM) was added 2 h prior to the addition of tetracycline. 

^bHalf-lives were calculated from plots of β-globin/GAPDH ratio against time. The half-lives shown are from two representative experiments. 

^cNM, not measurable.