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. Author manuscript; available in PMC: 2021 Dec 13.
Published in final edited form as: Regul Toxicol Pharmacol. 2019 Oct 29;109:104510. doi: 10.1016/j.yrtph.2019.104510

Figure 6. Heatmap of hormone response profiles.

Figure 6.

Putative aromatase inhibitors were identified after filtering HT-H295R response profiles for chemical samples with statistically significant decreases in E1 and E2 concentrations compared to plate-level DMSO controls (as measured by one-way ANOVA) with a fold decrease of ≥1.5. Rows denote chemical samples and columns are hormones. Rows were clustered using Ward’s method only considering ANDR, TESTO, E1, and E2, and four prominent clusters were identified and are labeled. The aromatase relevant hormones, specifically ANDR, TESTO, E1, and E2, are presented to the left whereas the other hormones are presented to the right. The log10-maxmMd value is also denoted with an annotation bar to the right to indicate effect size for the 11 hormones. Reference chemicals (chrysin, clotrimazole, metyrapone, letrozole, and fadrozole hydrochloride) known to inhibit aromatase are specifically labeled to the right (Judson et al., 2018b). Grey denotes missing data due to sample loss during screening. Cluster numbers 1-4 referenced in the text are labeled.