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. 2021 Nov;9(22):1672. doi: 10.21037/atm-21-5369

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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DSPP (NM_014208) variations were identified by Sanger sequencing in participants. (A) Sanger sequencing of the c.53T > G (p. Val18Gly) variant in DSPP. (B) Evolutionary conservation of the DSPP protein. Multiple amino acid sequence alignment of DSPP indicated conservation of valine (shown in red) at position 18 in different species. (C) The size and hydrophobicity of mutant residues are different from those of the wild type, which also changes the original characteristics of the DSP protein. WT, wild-type; DSPP, dentin sialophosphoprotein; DSP, dentin sialoprotein.