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. 2021 Nov;9(22):1672. doi: 10.21037/atm-21-5369

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Phenotypic and functional characteristics of hDPSCs from DGI patient. (A) Accumulation of calcium stained with alizarin red staining after growth of control cells and DGI cells (×10). (B) The mineralization ability of DGI cells was significantly lower than control cells, *, P<0.05. (C) The expression level of DSPP in DGI cells was significantly lower than in control cells, *, P<0.05. (D) The expression level of RUNX2 in DGI cells was significantly lower than in control cells, *, P<0.05. (E) The expression level of ALP in DGI and control cells showed no significant difference. hDPSCs, human dental pulp stem cells; DGI, dentinogenesis imperfecta; DSP, dentin sialoprotein; RUNX2, runt-related transcription factor 2; ALP, alkaline phosphatase.