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. 2021 Nov;9(22):1671. doi: 10.21037/atm-21-5476

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Anti-inflammatory effects of PDK1 silencing in LPS-induced ALI model. (A) Representative pictures of H&E staining (×200); (B) the content of MPO in four groups; (C-F) the concentrations of TNF-α, iNOS, IL-6, MCP-1 in 4 groups; (G,H) relative protein level of IL-6 and iNOS. *, P<0.05 vs. the sham group; ^#, P<0.05 vs. ALI model group. PDK1, 3-phosphoinositide-dependent kinase 1; LPS, lipopolysaccharide; mRNA, messenger RNA; ALI, acute lung injury; MPO, myeloperoxidase; TNF-α, tumor necrosis factor-α; iNOS, inducible nitric oxide synthase; IL-6, interleukin-6; MCP-1, monocyte chemoattractant protein-1.