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. 2021 Nov;9(22):1671. doi: 10.21037/atm-21-5476

Figure 5.

Figure 5

Effects of PDK1 silence on NF-kB p65 phosphorylation in LPS-induced ALI model. (A) Representative pictures of western blot assay and relative protein levels of TLR4, MyD88 and p-p65/p65; (B) representative pictures of western blot for the effect of asatone addition on p65 phosphorylation and relative protein level of p-p65/p65 in each group; (C) lung injury score; (D) minute ventilation (mL/kg); (E) Relative mRNA level of TGF-β; (F) relative mRNA level of α-SMA; (G) the concentrations of IL-6; (H) the concentrations of iNOS. *, P<0.05 vs. the sham group; #, P<0.05 vs. ALI model group. PDK1, 3-phosphoinositide-dependent kinase 1; LPS, lipopolysaccharide; ALI, acute lung injury; α-SMA, α-smooth muscle actin; IL-6, interleukin-6; iNOS, inducible nitric oxide synthase; p-p65, phosphorylated p65.