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. 2021 Nov;9(22):1660. doi: 10.21037/atm-21-5138

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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The effect of TGF-β pathway alterations in immune profiles and immunotherapy treatment outcomes. (A) Regulation of the immune-related gene expression patterns upon the altered TGF-β pathway in TCGA cohort. (B) Association of TGF-β pathway alterations and tumor-infiltrating cells in TCGA cohort. (C) Prognosis value of TGF-β pathway alterations in overall survival for pan-cancer patients in TCGA cohort. (D) The predictive role of TGF-β pathway alterations in overall survival for cancer patients treated with immune checkpoint inhibitors in the immune cohort. ***, P<0.001; ****, P <0.0001. TGF-β, transforming growth factor beta; TCGA, The Cancer Genome Atlas.