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. 2021 Nov 29;12:747944. doi: 10.3389/fendo.2021.747944

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Copyright © 2021 Yao, Wang, Zhang, Wang, Liu, Di, Song and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Brown adipose tissue (BAT) transplantation improved the reproductive phenotype of polycystic ovary syndrome (PCOS) model rats. (A) Disordered estrous cycles were observed in the DHEA+Sham group, while BAT transplantation rescued the abnormal estrous cycles. (B) Representative results of ovarian H&E staining of the control (Ctrl) group, DHEA+Sham group, and DHEA+BAT group. Ovarian histology revealed that cystic follicles (arrow) and a few corpora lutea (asterisk) appeared in the DHEA+Sham group compared with the Ctrl group, while BAT transplantation reversed the phenotype caused by dehydroepiandrosterone (DHEA). H&E, hematoxylin–eosin; D, diestrus; E, estrus; M, metestrus; P, proestrus; UCP1, uncoupling protein 1.