Table 2.

Results of the study.

	BLM To Control	BLM+P21 To BLM	BLM+P28 To BLM	P21 To Control	P28 To Control
Col1a1	↑	↑	↔	↑	↑
Col1a2	↑	↔	↓	↑	↑
α- SMA	↑	↔	↑	↔	↑
TGF-β	↑	↔	↑	↔	↑
Ctgf	↔	↑	↓	↔	↓
Edn1	↔	↔	↓	↔	↔
Mast cell	↔	↔	↔	↔	↔
MMP9	↑⁎	↔	↓	↔	↔
MMP2	↔⁎	↔	↔	↔	↔
TNF-α	↑	↓	↓	↔	↔
Cortisol	↓	↔	↑	↔	↔
Collagen	↑	↔	↑	↑	↑
Apoptosis⁎	↑	↔	↔	↔	↔
Fibrosis	↑	↔	↑	↑	↑

P, Progesterone; BLM, Bleomycin; Col1a1, Collagen Type I Alpha 1 Chain gene; Col1a2, Collagen Type I Alpha 2 Chain gene; α-SMA, Alpha smooth muscle actin; Ctgf, connective tissue growth factor gene; Edn1, Endothelin -1 gene; MMP9, Matrix metalloproteinase 9; MMP2, Matrix metalloproteinase 2. ↑ = increased, ↓ = decreased, ↔ = does not alter. ⁎ = results adapted from references (4) and (5).