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. 2021 Nov 29;12:769244. doi: 10.3389/fphar.2021.769244

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Copyright © 2021 Mahmoud, Abdelaal, Mohammed, El-Shazly, Daoud, Abdelfattah and Sobeh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Stained photomicrographs with Mallory trichrome of pancreatic sections presenting collage fibers distribution from normal rats (A), STZ diabetic rats (B), S. aqueum (SA) extract (100 mg/kg) (C), S. aqueum (SA) extract (200 mg/kg) (D), the reference drug, glibenclamide (E), and collagen area percent (%) (F). Results are presented as mean ± SEM. *Significant difference related to the normal control group and ^@related to STZ diabetic rats at p < 0.05 by One-Way ANOVA and Tukey post hoc test, n = 6. Zigzag arrow indicating blue staining of the collagen of (IL) Langerhans islets and (D) duct. Scale bar: 50 μm.