Table 1.
Time-course changes of biological data in the index case
| Day/ month | WBC count (/mm3) |
Lymphocyte count (%) |
Bilirubin (mg/dL) | ALT (IU/L) |
Triglycerides (mg/dL) |
Total cholesterol (mg/dL) |
HDL-C (mg/dL) | LDL-C (mg/dL) | VLDL-C (mg/dL) | Lp(a)-C (mg/dL) | IgM-VCA | IgG-VCA | Anti-EBNA |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 23/1 | 10,240 | 67 | 9.9 | 207 | 360 | ND | ND | ND | ND | ND | (+) | (-) | (-) |
| 27/1 | 6300 | 73 | 7.1 | 183 | 367 | 697 | 18 | 583 | 93 | 3 | ND | ND | ND |
| 05/2 | 7420 | 59 | 3.8 | 143 | 1492 | 610 | 31 | 277 | 299 | 0 | ND | ND | ND |
| 11/2 | 6940 | 47 | 2.9 | 155 | 302 | 455 | 26 | 328 | 96 | 0 | ND | ND | ND |
| 24/2 | 7790 | 35 | 1.5 | 65 | 175 | 227 | ND | ND | ND | ND | ND | ND | ND |
| 27/3 | 6410 | 36 | 0.5 | 30 | 114 | 205 | ND | ND | ND | ND | ND | ND | ND |
| 16/4 | 7520 | 37 | 0.5 | 62 | 193 | 216 | 39 | 134 | 43 | 2 | (+) | (+) | (-) |
| 03/6 | 6000 | 38 | 0.3 | 36 | 147 | 242 | ND | ND | ND | ND | (+/-) | (+) | (-) |
| 04/8 | 8020 | 37 | 0.5 | 25 | 178 | 211 | 34 | 133 | 44 | 2 | (-) | (+) | (+) |
Cells counts were performed in venous blood. Biochemical determinations and microbiological studies were performed in serum
WBC, white blood cell count. ALT, alanine aminotransferase. VCA, Epstein-Barr virus capsid antigen. EBNA, Epstein-Barr virus nuclear antigen. HDL-C, high-density lipoprotein cholesterol. LDL-C, low-density lipoprotein cholesterol. VLDL-C, very low-density lipoprotein cholesterol. Lp(a)-C, lipoprotein-A cholesterol. Cholesterol fractions [HDL-C, LDL-C, VLDL-C, and Lp(a)-C] were measured by agarose gel electrophoresis. ND, no data available
(+), positive. (-), negative. (+/-), indeterminate value
The patient was treated with fenofibrate (600 mg bid, po) from 05/2 to 27/3