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Effects of S1 7d post-ICM injection on neuroinflammatory genes. Rats were injected ICM with vehicle (1x PBS) or S1 (1 μg). 7d after ICM injection, gene expression of glial activation markers and neuroinflammatory-related genes was measured in (A) hypothalamus, (B) hippocampus and (C) frontal cortex. Data are presented as the mean + SEM. N = 6/group. S1 vs vehicle, *p < 0.05, **p < 0.01, ***p < 0.001.
