Table 3.

Performance comparisons for the methods before and after integrating with hand-crafted biological features (take Spearman correlation coefficient as evaluation index)

Method	WT-SpCas9		eSpCas9(1.1)		SpCas9-HF1
	Mean	SD (× 10–3)	Mean	SD (× 10–3)	Mean	SD (× 10–3)
RNN*	0.856	3.33	0.849	5.00	0.851	4.11
EnAC	0.868	2.66	0.859	4.66	0.862	3.19
DeepHF*	0.867	2.37	0.862	4.24	0.860	3.21
StAC	0.872	2.55	0.867	3.71	0.867	2.65

The method with superscript of * and # have been reported respectively [15, 17]. In the tables, we use the results reported in the relevant papers as the performance of the method directly