Table 1.

Some clinical studies conducted on the use of l-carnitine in relieving fatigue.

Authors(s)	Number of patients	Dosage	Results
Gramignano et al. 2005 [11]	12 cancer patients with fatigue Average age: 60 years	Oral use of 6 g per day for 4 weeks	Considerable increase in nutritional variables (lean body mass and appetite) after taking l-carnitine supplement Decreased reactive oxygen levels Increased glutathione peroxidase No significant change in proinflammatory cytokines
Crucianie et al. (2006) [17]	38 cancer patients with fatigue	Doses of 250, 750, 1250, 1750, 2250, 2750, and 3000 mg were used twice daily for 7 days	Improvement of fatigue, mood, and sleep in most patients Improvement of dose-dependent fatigue
Matsui et al. 2017 [6]	11 cancer patients with fatigue Average age: 67 years	Daily consumption of 1500 mg for 8 weeks	Reduction of fatigue in all patients Retained plasma levels of albumin and lymphocytes throughout chemotherapy
Vasiljevski et al. 2021 [14]	6 children with neurofibromatosis type 1 (NF1) and fatigue Average age: 10 years	Daily use of 1000 mg oral l-carnitine supplement for 12 weeks	Safety of the use of l-carnitine supplement for 12 weeks in children with NF1
AbuMoh'd et al. 2021 [13]	20 athletes In two groups of l-carnitine and placebo Average age: 67 years	2 × 1.5 g per day for 3 weeks	There was a better physiological respond to l-carnitine supplement compared with the placebo group