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. 2021 Nov 29;9:784367. doi: 10.3389/fcell.2021.784367

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Copyright © 2021 Egea.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diffusive transfer of phosphatidic acid between mitochondrial membranes by the soluble LTP Ups1/Mdm35. (A) Structures of the apo and PA-bound Ups1/Mdm35 soluble LTP complexes emphasizing the polar arginine clasp (sphere) at the bottom of the PA-binding pocket, the Ω-loop (orange) sealing the hydrophobic cavity entrance and involved in membrane attachment and PA extraction. The apo and holo structures are shown in the same orientation. (B) Simplified cycle for the diffusive LTP-assisted transfer of PA between mitochondrial membranes. Mdm35 reversible dissociation from Ups1 enhances its membrane association. Diffusive transfer is driven by the PA concentration gradient as transferred PA fuels CL biosynthesis (PDB 5QJM-5YTX).