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. Author manuscript; available in PMC: 2021 Dec 13.
Published in final edited form as: Cell Rep. 2021 Nov 9;37(6):109968. doi: 10.1016/j.celrep.2021.109968

Figure 5. METTL3 controls metabolic adaptation in macrophage effector function in obesity and NAFLD.

Figure 5.

(A–C) Eight- to 10-week-old KO mice and WT littermates were fed with HFD for 16 weeks as described in Figure 2. qRT-PCR analysis of the mRNA abundance of the indicated genes in (A) liver tissue, (B) scWAT tissue, and (C) KCs isolated form HFD-fed mice.

(D) ELISA analysis of IL-1β protein secretion in serum from HFD-fed mice.

(E) Western blot of IκBα and DDIT4 protein levels in liver tissues from HFD-fed mice.

(F) Schema of myeloid METTL3 promoted NAFLD and obesity development associated at least in part with the translation of m6A-decorated DDIT4 gene transcripts. Data represent mean ± SD (n = 10–15). Two-tailed Student’s t test or two-way ANOVA: *p < 0.05; **p < 0.01.