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. Author manuscript; available in PMC: 2022 Jun 15.
Published in final edited form as: J Am Coll Cardiol. 2021 Jun 15;77(23):2939–2959. doi: 10.1016/j.jacc.2021.04.035

Figure 8. Risk of Coronary Events, According to Genetic and Lifestyle Risk.

Figure 8.

Shown are adjusted hazard ratios for coronary events in each of the three prospective cohorts, according to genetic risk and lifestyle risk: the Atherosclerosis Risk in Communities (ARIC) cohort, the Women’s Genome Health Study (WGHS) cohort, and the Malmö Diet and Cancer Study (MDCS) cohort. In these comparisons, participants at low genetic risk with a favorable lifestyle served as the reference group. There was no evidence of a significant interaction between genetic and lifestyle risk factors (P = 0.38 for interaction in the ARIC cohort, P = 0.31 in the WGHS cohort, and P = 0.24 in the MDCS cohort). Unadjusted incidence rates are reported per 1000 person-years of follow-up. A random-effects meta-analysis was used to combine cohort-specific results. Republished with permission from Khera AV, Emdin CA, Drake I, et al. Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease. N Engl J Med. 2016 Dec 15;375(24):2349–2358.