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Summary of activation of Ras mutants
| Mutant | Phosphorylation of:
|
% Viability 48 h after IL-3 starvation | ||
|---|---|---|---|---|
| p42/MAPK | p70/S6K | Akt | ||
| Ras(G12V) | + | + | + | >90 |
| Ras(G12V) + wortmannin | + | − | − | 80 |
| Ras(G12V) + rapamycin | + | − | + | 80 |
| Ras(G12V/V45E) | − | + | + | 75 |
| Ras(G12V/V45E) + wortmannin | − | − | − | <10 |
| Ras(G12V/V45E) + rapamycin | − | − | + | <20 |
