A, Using the Johnson–Neyman technique, the simple slope of CD4 count is only significant above 1.25 symptoms of frailty, such that the lower CD4 count relates to higher likelihood of HAND among participants with >1.25 frailty symptoms. B, The negative relationship between CD4 count and likelihood of HAND among participants with 2–5 frailty symptoms is depicted by the solid line. By contrast, the CD4 count is not significantly related to the likelihood of HAND among participants with 0–1 frailty symptoms, as depicted by the dashed line. C, Using the Johnson–Neyman technique, the simple slope of frailty is only significant at or below a CD4 count of 642, such that higher frailty relates to higher likelihood of HAND among participants with ≤642 CD4 cells. D, The positive relationship between frailty symptoms and the likelihood of HAND among participants with ≤642 CD4 cells, as depicted by the dashed line. By contrast, frailty symptoms are not significantly related to the likelihood of HAND among participants with >642 CD4 cells, as depicted by the solid line.