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. 2021 Nov 3;110(6):1225–1239. doi: 10.1002/JLB.4COVA0121-084RR

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©2021 Society for Leukocyte Biology

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Corticosteroids treatment modulates transcriptional responses in acute COVID-19. Venn diagrams representing DEGs between corticosteroid (CORT)-treated and untreated (NC) for (A) young and (B) aged patients. Functional enrichment of CORT-unique, NC-unique and shared DEGs in panels (A) and (B) for (C) young and (D) aged cohorts. Color intensity represents the statistical significance (shown as the negative log of the FDR-adjust P-value, -log(q-value)) with a range of colors based on the GO terms with the lowest and highest –log(q-value) values for the entire set of genes per cluster. Numbers of genes enriching to each GO term per cluster are represented in each box; blank boxes indicate no statistical significance