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. 2021 Nov 3;110(6):1225–1239. doi: 10.1002/JLB.4COVA0121-084RR

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©2021 Society for Leukocyte Biology

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Genes related to humoral immunity and DNA metabolism are longitudinally downregulated in aged CORT-treated patients. (A) Functional enrichment of LRGs identified for aged CORT-treated patients only. Color of each bar color represents the FDR-corrected P-value (q-value). (B) Expression of LRGs from panel (B). Each column represents the average (or singular value) rpkm for the given timepoint. Range of colors is based on row-scaled and centered rpkm values of the represented DEGs. Red represents upregulation; blue represents down-regulation. (C) Expression of longitudinal-regulated genes (LRGs) (DD6, RAB2A, UBE2S, VAC14) longitudinally regulated in aged and young corticosteroids (CORT)-treated patients