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. 2021 Nov 29;9:761773. doi: 10.3389/fcell.2021.761773

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Copyright © 2021 He, Xie, Zheng, Zhang, Ma, Li, Li and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nuclear TFE3 expression is reduced in the SN dopaminergic neurons of PD patients. (A) Sections of human SN obtained from PD or control subjects were immunostained using a TFE3 antibody visualized by DAB staining (gray-black) and a Iba1 antibody visualized by ImmPACT Vector Red staining (magenta). Scale bars: upper panel: 50 μm; lower panel: 10 μm. (B) Quantification of the nuclear to cytoplasmic ratios of TFE3 in human SN dopaminergic neurons. n = 436 dopaminergic neurons from 5 PD patients and 898 dopaminergic neurons from five controls, respectively. Data are expressed as the mean ± SEM. ****p < 0.0001, two-tailed Student’s t test.