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. 2021 Nov 29;12:714163. doi: 10.3389/fphar.2021.714163

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Copyright © 2021 Zheng, Zhang, Huang, Zhong, Wang, Wang, Yang, Wang, Pan, Situ, Lin, Liu, Shi and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SNS inhibits CUMS-induced lung metastasis and stemness of breast cancer. SNS interrupts the interaction between GRP78 and LRP5 on the cell surface, thus inhibiting the Wnt/β-catenin signaling of breast CSCs.