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. Author manuscript; available in PMC: 2022 Nov 17.
Published in final edited form as: Nat Prod Rep. 2021 Nov 17;38(11):2066–2082. doi: 10.1039/d1np00040c

Fig. 3.

Fig. 3.

(a) Left: Two-dimensional emperor plots displaying the prinicipal component analysis (based on MS/MS data) of files in ReDU (n = 40,919) colored by SampleType. Middle: Highlighting via filtering of bacterial files in ReDU, n = 2,246 files. Right: Highlighting specific bacterial files based on taxonomy in ReDU with gut-associated bacterial in dark grey and all other bacterial files in light grey. (b) Left: Illustration displaying the gut-associated bacterial genera selected for Group Comparator analysis (created with BioRender.com). Right: Dot plots displaying the Group Comparator results (percentage of files in which an annotated spectrum was observed) of three of the most abundant diketopiperazines: cyclo(Pro-Leu), cyclo(Leu-4-hydroxy-Pro) and cyclo(Phe-Leu).