TABLE 4.
Functional enrichment of the core targets of BTP-DEGs.
| Term | Category | Count | p Value | Gene ratio |
|---|---|---|---|---|
| KEGG | PI3K-Akt signaling pathway | 9 | 2.982E-13 | 52.94117647 |
| Prostate cancer | 5 | 1.505E-09 | 29.41176471 | |
| Pathways in cancer | 7 | 1.745E-09 | 41.17647059 | |
| Cell cycle | 5 | 9.05E-09 | 29.41176471 | |
| Estrogen signaling pathway | 4 | 3.169E-07 | 23.52941176 | |
| Protein processing in endoplasmic reticulum | 4 | 2.61E-06 | 23.52941176 | |
| Hepatitis C | 4 | 2.802E-06 | 23.52941176 | |
| Proteoglycans in cancer | 4 | 5.796E-06 | 23.52941176 | |
| Central carbon metabolism in cancer | 3 | 7.797E-06 | 17.64705882 | |
| Small cell lung cancer | 3 | 1.689E-05 | 17.64705882 | |
| Progesterone-mediated oocyte maturation | 3 | 2.521E-05 | 17.64705882 | |
| Endocrine resistance | 3 | 2.521E-05 | 17.64705882 | |
| Oocyte meiosis | 3 | 5.416E-05 | 17.64705882 | |
| Fluid shear stress and atherosclerosis | 3 | 8.104E-05 | 17.64705882 | |
| Breast cancer | 3 | 8.447E-05 | 17.64705882 | |
| GO BP | DNA repair | 8 | 5.631E-10 | |
| cell cycle phase transition | 8 | 1.399E-09 | ||
| regulation of cell cycle phase transition | 7 | 6.522E-09 | ||
| regulation of the cell cycle process | 8 | 7.122E-09 | ||
| G1/S transition of the mitotic cell cycle | 6 | 9.284E-09 | ||
| cell cycle G1/S phase transition | 6 | 1.498E-08 | ||
| mitotic cell cycle phase transition | 7 | 2.936E-08 | ||
| positive regulation of the cell cycle | 6 | 7.962E-08 | ||
| DNA biosynthetic process | 5 | 9.436E-08 | ||
| response to the topologically incorrect protein | 5 | 1.149E-07 | ||
| protein insertion into the membrane | 4 | 1.196E-07 | ||
| proteasome-mediated ubiquitin-dependent protein catabolic process | 6 | 1.243E-07 | ||
| regulation of mitotic cell cycle phase transition | 6 | 1.484E-07 | ||
| regulation of cell cycle G2/M phase transition | 5 | 1.558E-07 | ||
| developmental growth involved in morphogenesis | 5 | 1.782E-07 | ||
| GO MF | ubiquitin protein ligase binding | 9 | 2.855E-14 | |
| ubiquitin-like protein ligase binding | 9 | 5.039E-14 | ||
| nitric-oxide synthase regulator activity | 4 | 1.142E-11 | ||
| disordered domain specific binding | 4 | 4.166E-09 | ||
| Kinase binding | 8 | 4.315E-09 | ||
| protein kinase binding | 7 | 5.903E-08 | ||
| protein domain specific binding | 7 | 8.076E-08 | ||
| Protease binding | 4 | 1.015E-06 | ||
| cell adhesion molecule binding | 5 | 1.313E-05 | ||
| histone deacetylase binding | 3 | 4.105E-05 | ||
| unfolded protein binding | 3 | 4.912E-05 | ||
| integrin binding | 3 | 8.104E-05 | ||
| protein phosphatase binding | 3 | 9.162E-05 | ||
| Phosphatase binding | 3 | 0.0002008 | ||
| chromatin binding | 4 | 0.0002956 | ||
| GO CC | vesicle lumen | 5 | 1.147E-06 | |
| melanosome | 3 | 3.392E-05 | ||
| pigment granule | 3 | 3.392E-05 | ||
| secretory granule lumen | 4 | 3.55E-05 | ||
| cytoplasmic vesicle lumen | 4 | 3.725E-05 | ||
| perinuclear region of the cytoplasm | 5 | 5.163E-05 | ||
| ficolin-1-rich granule lumen | 3 | 5.416E-05 | ||
| intracellular protein-containing complex | 5 | 5.621E-05 | ||
| focal adhesion | 4 | 9.86E-05 | ||
| cell-substrate junction | 4 | 0.0001051 | ||
| growth cone | 3 | 0.0001582 | ||
| neuronal cell body | 4 | 0.0001585 | ||
| site of polarized growth | 3 | 0.0001744 | ||
| ficolin-1-rich granule | 3 | 0.0001772 | ||
| protein-DNA complex | 3 | 0.0002502 |