Table 3.

Interaction parameters of different ligands with γ-secretase.

Ligands	Hydrogen bonding	Pi-Sigma	Pi-Pi	Pi-Alkyl	van der Waals’ interaction
55E	–	–	Phe 6	Phe 18	Phe 7, Thr 10, Ile 127, Val 131, Val 134, Ile 135, Leu 138
6Z2	–	–	Phe 411	Ile 408	Phe 21, Val 32, Leu 35, Val 36, Ile 83, Phe 86, Val 87, Thr 90, Met 93, Val 94, Ile 127, Val 131, Val 412
BRW	–	Ala 426	–	Val 82, Leu 423	Lys 37, Thr 74, Leu 75, Gly 78, Val 379, Cys 419, Leu 422, Leu 425
6Z5	Asn 2, *Phe 35, Arg 39		–	Leu 3, Val 32, Trp 36, Arg 220, Leu 221	Phe 37, Phe 38, Glu 40, Leu 319
F1B	Thr 10	–	Phe 14		Phe 6, Phe 7, phe 11, Ala 17, Phe 18, Phe 21, Ile 127, Val 131, Ile 135
GVP	–		Phe 411	Val 36, Ala 39, Ile 408, Val 412	Leu 35, Met 93, Val 94, Val 97, Ile 128, Val 131, Thr 393, Thr 407
IQ6	–	–	Phe 14	Phe 6, Phe 11, Ala 17, Phe 18, Ile 127, Val 131, Leu 680	Thr 10, Gly 15, Ile 135
X37	*Thr 10, Phe 14	Pro105	Phe 2	–	Phe 11, Ala 17, Phe 18, Val 32, Leu 35, Val 36, Ile 127, Phe 411

*Occurrence of two hydrogen bonds.