Scheme 1.
Synthetic Routes and Conditions for the Preparation of New Analogsa
a(a) HOAc (gl), then add cinnamoyl chloride, rt, 12 h. (b) HOAc (gl), then add naphthyl chloride, rt, 12 h. (c) LiOH, THF-H2O (9:1). (d) TBTU, CH2Cl2, 4-Me piperazine. (e) 15 or 16, Pd(PPh3)4, K2CO3, microwave, ArB(OH)2.