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. Author manuscript; available in PMC: 2022 Sep 10.
Published in final edited form as: ACS Infect Dis. 2021 Aug 11;7(9):2650–2665. doi: 10.1021/acsinfecdis.1c00100

Scheme 1.

Scheme 1.

Synthetic Routes and Conditions for the Preparation of New Analogsa

a(a) HOAc (gl), then add cinnamoyl chloride, rt, 12 h. (b) HOAc (gl), then add naphthyl chloride, rt, 12 h. (c) LiOH, THF-H2O (9:1). (d) TBTU, CH2Cl2, 4-Me piperazine. (e) 15 or 16, Pd(PPh3)4, K2CO3, microwave, ArB(OH)2.