Table 5.
MIC and Potentiation Data for Selected EPIs in E. cloacae and K. pneumoniaed
|
E. cloacae ATCC13047 |
K. pneumoniae ATCC13883 |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| # | MICa | MPC4b (NOV) | Fold MICc (NOV) | MPC4b (ERY) | fold MICc (ERY) | MPC4b (CIP) | fold MICc (CIP) | MICa | MPC4b (NOV) | fold MICc (NOV) | MPC4b (CIP) | fold MICc (CIP) | MPC4b (CIP) | fold MICc (CIP) |
| NOV | 400 | NA | NA | NA | NA | NA | NA | 50 | NA | NA | NA | NA | NA | NA |
| ERY | 400 | NA | NA | NA | NA | NA | NA | 400 | NA | NA | NA | NA | NA | NA |
| CIP | 0.031 | NA | NA | NA | NA | NA | NA | 0.031 | NA | NA | NA | NA | NA | NA |
| 2 | >100 | 12.5 | 64 | 12.5 | 8 | >100 | 1 | >100 | 12.5 | 64 | >100 | 2 | >100 | 1 |
| 6 | >100 | 25 | 64 | 50 | 2 | >100 | 1 | >100 | >100 | 1 | >100 | 1 | 25 | 4 |
| 7 | 50 | 25 | 4 | >100 | 1 | >100 | 1 | 100 | 25 | 8 | 100 | 1 | 25 | 4 |
| 8 | >100 | 25 | 32 | 25 | 8 | >100 | 1 | >100 | 25 | 64 | 100 | 1 | 25 | 4 |
| 10 | >100 | 12.5 | 32 | 6.25 | 8 | >100 | 1 | 25 | 6.25 | NA | 50 | 1 | 25 | NA |
| 11 | >100 | 12.5 | 32 | >100 | 1 | >100 | 1 | 50 | 12.5 | 64 | 50 | 1 | 12.5 | NA |
| 13 | >100 | 50 | 1 | 50 | 1 | >100 | 1 | 100 | 25 | 16 | 100 | 1 | 25 | 8 |
| 15 | >100 | 100 | 2 | 100 | 1 | ND | ND | >100 | 100 | 1 | >100 | 1 | ND | ND |
| 16 | >100 | >100 | 1 | >100 | 1 | ND | ND | >100 | >100 | 1 | >100 | 1 | ND | ND |
| 21 | >100 | 25 | 1 | >100 | 1 | ND | ND | >100 | >100 | 1 | >100 | 1 | ND | ND |
| 28 | >100 | >100 | 1 | >100 | 1 | ND | ND | >100 | >100 | 1 | >100 | 1 | ND | ND |
| 33 | >100 | >100 | 1 | >100 | 1 | ND | ND | 100 | 12.5 | 64 | 50 | 1 | ND | ND |
| 34 | >100 | >100 | 1 | 25 | 64 | ND | ND | >100 | >100 | 1 | >100 | 1 | ND | ND |
| 36 | >100 | >100 | 1 | >100 | 1 | ND | ND | >100 | 50 | 1 | >100 | 1 | ND | ND |
a
MIC values (μM for test compounds, mg/L for antibiotics), determined as the average of two replicates.
b
Minimum concentration of test compounds required to reduce the MIC of novobiocin (NOV), erythromycin (ERY), or ciprofloxacin (CIP) by 4-fold measured in the indicated strains.
c
The ratio of MIC values for novobiocin, erythromycin, and ciprofloxacin in the absence and presence of 25 μM of test compounds.
d
ND = no data; NA = not applicable.