Tests to investigate parasympathetic function |
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Heart rate response to deep breathing |
Beat‐to‐beat variation while the patient breathes in and out (b.p.m.) |
≥15 |
11–14 |
≤10 |
Heart rate response to standing |
30:15 ratio (ratio of R‐R interval measured at beats 30 and 15 after standing) |
≥1.04 |
1.01–1.03 |
≤1.00 |
Heart rate response to Valsalva maneuver |
Valsalva ratio (ratio of longest to shortest R‐R interval measured while performing the Valsalva maneuver) |
≥1.21 |
1.11–1.20 |
≤1.10 |
Tests to investigate sympathetic function |
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Blood pressure response to standing |
Decrease in systolic pressure by supine to standing |
≤10 mmHg |
11–29 mmHg |
≥30 mmHg |
Blood pressure response to sustained handgrip |
Increase in diastolic pressure by squeezing a handgrip dynamometer |
≥16 mmHg |
11–15 mmHg |
≤10 mmHg |