Table 10.
CGCM, %1 | P-value | ||||||
---|---|---|---|---|---|---|---|
Item | 0 | 0.7 | 1.4 | 2.1 | SEM | Linear | Quadratic |
Proximal2 jejunal tissue | |||||||
Villus height, μm | 509 | 447 | 481 | 444 | 27 | 0.190 | 0.649 |
Villus width, μm | 121 | 118 | 117 | 116 | 6 | 0.451 | 0.890 |
Crypt depth, μm | 257 | 239 | 277 | 264 | 46 | 0.439 | 0.878 |
VH:CD3 | 2.05 | 1.96 | 1.86 | 1.74 | 0.33 | 0.090 | 0.905 |
Ki-67+4, % | 10.1 | 10.9 | 12.7 | 10.6 | 2.1 | 0.581 | 0.292 |
Distal5 jejunal tissue | |||||||
Villus height, μm | 307 | 327 | 291 | 386 | 31 | 0.165 | 0.233 |
Villus width, μm | 97 | 97 | 96 | 106 | 5 | 0.189 | 0.288 |
Crypt depth, μm | 262 | 277 | 281 | 288 | 15 | 0.257 | 0.796 |
VH:CD | 1.17 | 1.23 | 1.05 | 1.39 | 0.11 | 0.357 | 0.214 |
Ki-67+, % | 10.3 | 13.4 | 12.6 | 10.3 | 1.5 | 0.833 | 0.004 |
1Four supplemental levels of CGCM (n = 32 total, n = 8 per supplemental level).
2Proximal jejunum: 1.5 m after the pyloric duodenal junction.
3VH:CD, villus height to crypt depth ratio.
4Ki-67+, enterocyte proliferation rate in crypt.
5Distal jejunum: 1.5 m before the ileocecal junction.