Table 4.

Multivariate Adjusted ORs for the Association Between LDH Levels and PSD at Discharge

	Tertile	ORa	95% CI	P-Value
Unadjusted	Middle	1.502	0.978–2.305	0.063
	Upper	2.100	1.366–3.228	0.001
Model 1b	Middle	1.485	0.966–2.284	0.072
	Upper	2.007	1.301–3.095	0.002
Model 2c	Middle	1.485	0.966–2.284	0.072
	Upper	2.007	1.301–3.095	0.002
Model 3d	Middle	1.516	0.955–2.406	0.078
	Upper	1.601	1.002–2.558	0.042
Model 4e	Middle	1.516	0.955–2.406	0.078
	Upper	1.601	1.002–2.558	0.042

Notes: ^aReference OR (1.000) is the lowest tertile of LDH for PSD. ^bModel 1: Adjusted for age, gender, educational level, body mass index and marital status. ^cModel 2: Adjusted for covariates from model 1 and further adjusted for history of smoking and drinking, medical history (coronary artery disease, diabetes mellitus, hyperlipidemia, hypertension, previous stroke, atrial fibrillation and surgery). ^dModel 3: Adjusted for covariates from model 2 and further adjusted for baseline NIHSS scores, mRS scores, Barthel Index scores, hospitalization days and hospital. ^eModel 4: Adjusted for covariates from model 3 and further adjusted for CRP, IL-1β, IL-6, IL-10, TNF-α, BDNF, IFN-γ and IL-18.

Abbreviations: OR, odds ratio; LDH, lactate dehydrogenase; PSD, post-stroke depression; CI, confidence interval.