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. 2021 Nov 29;8:775743. doi: 10.3389/fmolb.2021.775743

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Copyright © 2021 Gao, Liu, Yang, He, Wu, Zhang and Dong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Endogenous SPARC overexpression promote liver cancer cells proliferation and tumor growth. (A) qRT-PCR showed the higher SPARC expression level in HepG2^SPARC. (B) SPARC overexpression promotes liver cancer cell proliferation. (C) FCM showed the effects of SPARC overexpression on cell cycle. (D) FCM showed the effects of SPARC overexpression on cell apoptosis. (E) SPARC overexpression promotes tumor growth in vivo.