Table 1.
Curative effect of 90% methanolic leaf extract of SL in established infection (Rane assay).
| Drug | Dose mg/kg | Parasitemia | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | Day 8 | MST (Days) |
|---|---|---|---|---|---|---|---|---|---|
| 5% DMSO | 0.2 ml | % parasitemia | 11.31 ± 0.28 | 13.49 ± 1.04 | 15.38 ± 0.64 | 18.3 0 ± 0.42 | 20.47 ± 0.34 | 16.31 ± 0.51 | 8.43 |
| % inhibition | 0 | 0 | 0 | 0 | 0 | 0 | |||
| CQ | 10 | % parasitemia | 11.66 ± 0.32 | 10.70 ± 0.84 | 4.38 ± 0.68 | 1.39 ± 0.24 | 0 ± 0 | 0 ± 0 | 21∗ |
| % inhibition | -3.09 | 20.68 | 71.52 | 92.40 | 100 | 100 | |||
| SL | 100 | % parasitemia | 10.61 ± 0.00 | 11.84 ± 0.00 | 10.44 ± 0.00 | 9.01 ± 0.00 | 7.75 ± 0.00 | 6.16 ± 0.00 | 21∗ |
| % inhibition | 6.19 | 12.23 | 31.99 | 50.77 | 62.14 | 71.09∗ | |||
| 200 | % parasitemia | 10.86 ± 0.00 | 12.26 ± 0.00 | 10.59 ± 0.00 | 9.04 ± 0.00 | 7.47 ± 0.00 | 5.84 ± 0.00 | 21∗ | |
| % inhibition | 3.98 | 9.12 | 31.01 | 50.60 | 63.51 | 72.60∗ | |||
| 400 | % parasitemia | 11.35 ± 0.00 | 12.62 ± 0.00 | 11.13 ± 0.00 | 8.81 ± 0.00 | 6.91 ± 0.00 | 7.76 ± 0.00 | 14.36∗ | |
| % inhibition | -0.35 | 6.45 | 27.49 | 51.86 | 66.24 | 62.09∗ |
Values for mean % parasitemia are expressed as mean ± standard error of the mean (± SEM) n = 5, significant at ∗P < 0.05 when compared with the control. SL: Sansevieria liberica extract; CQ: chloroquine; MST: mean survival time (days).