Table 2.
Comparison of anthropometric, clinical, hormonal, metabolic, and biochemical parameters in dominant genotype model for INSR rs1799817 SNP in PCOS women.
| Parameter | PCOS | P value | Controls | P value | ||
|---|---|---|---|---|---|---|
| CC + CT (n = 230) | TT (n = 19) | CC + CT (n = 88) | TT (n = 12) | |||
| Age (years) | 22.48 ± 4.19 | 21.88 ± 3.64 | 0.54 | 22.03 ± 3.15 | 21.83 ± 3.46 | 0.83 |
| Weight (kg) | 59.86 ± 11.71 | 61.53 ± 11.18 | 0.54 | 51.64 ± 6.61 | 54.17 ± 7.37 | 0.22 |
| Height (m) | 1.57 ± 0.05 | 1.55 ± 0.04 | 0.09 | 1.56 ± 0.05 | 1.58 ± 0.07 | 0.21 |
| BMI (kg/m2) | 24.23 ± 4.74 | 25.55 ± 4.37 | 0.24 | 21.08 ± 2.42 | 21.75 ± 2.89 | 0.38 |
| Waist (cm) | 83.17 ± 11.25 | 82.76 ± 10.74 | 0.87 | 76.59 ± 6.68 | 80.08 ± 9.47 | 0.11 |
| Hip (cm) | 93.39 ± 8.37 | 95.00 ± 7.57 | 0.48 | 90.82 ± 5.88 | 94.83 ± 8.46 | 0.03∗ |
| WHR | 0.89 ± 0.08 | 0.88 ± 0.07 | 0.59 | 0.84 ± 0.05 | 0.84 ± 0.06 | 1.00 |
| WHtR | 0.53 ± 0.07 | 0.53 ± 0.07 | 1.00 | 0.49 ± 0.04 | 0.51 ± 0.06 | 0.13 |
| BAI | 29.44 ± 4.78 | 31.18 ± 3.68 | 0.12 | 28.46 ± 3.01 | 29.80 ± 3.13 | 0.15 |
| SBP (mmHg) | 120.88 ± 7.45 | 118.41 ± 8.12 | 0.16 | 118.59 ± 5.49 | 121.67 ± 3.89 | 0.06 |
| DBP (mmHg) | 80.86 ± 5.87 | 80.65 ± 6.38 | 0.88 | 79.01 ± 5.34 | 81.58 ± 3.70 | 0.11 |
| Menarche (yr) | 13.14 ± 1.14 | 12.88 ± 1.17 | 0.34 | 13.30 ± 1.11 | 13.17 ± 0.83 | 0.69 |
| FG score | 13.99 ± 6.60 | 15.71 ± 6.59 | 0.27 | 4.59 ± 1.79 | 4.08 ± 2.23 | 0.37 |
| LH (IU/L) | 11.36 ± 9.82 | 10.15 ± 5.15 | 0.59 | 6.74 ± 2.37 | 6.00 ± 2.19 | 0.30 |
| FSH (IU/L) | 6.15 ± 1.85 | 5.77 ± 2.08 | 0.39 | 6.91 ± 1.99 | 6.83 ± 1.94 | 0.89 |
| TT (ng/dL) | 60.62 ± 21.28 | 72.31 ± 38.94 | 0.03 | 33.85 ± 15.06 | 36.32 ± 19.75 | 0.60 |
| SHBG (nmol/L) | 50.20 ± 21.75 | 49.31 ± 21.69 | 0.86 | 66.13 ± 25.51 | 55.97 ± 23.89 | 0.19 |
| Andro (ng/mL) | 3.26 ± 0.87 | 3.16 ± 0.79 | 0.62 | 2.22 ± 0.69 | 2.52 ± 0.62 | 0.15 |
| DHEAS (ng/mL) | 3.79 ± 1.16 | 3.74 ± 1.08 | 0.85 | 2.78 ± 1.29 | 3.83 ± 1.02 | 0.00∗ |
| Insulin (μIU/ml) | 13.29 ± 6.88 | 15.29 ± 7.94 | 0.23 | 7.52 ± 4.78 | 9.17 ± 8.88 | 0.32 |
| Glu F (mg/dL) | 85.60 ± 8.51 | 88.35 ± 10.01 | 0.18 | 84.17 ± 8.97 | 87.25 ± 7.88 | 0.26 |
| Glu 2 h (mg/dL) | 114.72 ± 18.08 | 122.18 ± 18.89 | 0.08 | 108.23 ± 12.83 | 110.92 ± 23.00 | 0.54 |
| Chol (mg/dL) | 154.80 ± 35.04 | 156.00 ± 31.43 | 0.88 | 133.58 ± 19.14 | 146.33 ± 17.29 | 0.03∗ |
| TG (mg/dL) | 120.78 ± 35.62 | 119.88 ± 38.82 | 0.91 | 102.76 ± 14.54 | 102.50 ± 17.13 | 0.95 |
| HOMA-IR | 2.85 ± 1.62 | 3.71 ± 1.92 | 0.02∗ | 1.56 ± 1.01 | 2.04 ± 2.03 | 0.18 |
| QUICKI | 0.33 ± 0.02 | 0.32 ± 0.02 | 0.03∗ | 0.37 ± 0.04 | 0.39 ± 0.08 | 0.16 |
| FAI | 5.76 ± 5.72 | 6.33 ± 4.30 | 0.67 | 2.17 ± 1.70 | 2.53 ± 1.33 | 0.48 |
| LH:FSH | 1.88 ± 1.22 | 1.84 ± 1.09 | 0.89 | 1.05 ± 0.57 | 0.91 ± 0.29 | 0.40 |
| LAP | 35.51 ± 21.74 | 35.43 ± 22.71 | 0.98 | 21.69 ± 8.52 | 25.94 ± 12.29 | 0.12 |
| Urea | 22.63 ± 6.09 | 23.88 ± 5.19 | 0.38 | 21.34 ± 3.58 | 21.12 ± 2.62 | 0.83 |
| Cre (mg/dL) | 1.04 ± 0.43 | 0.85 ± 0.20 | 0.05 | 0.81 ± 0.14 | 0.78 ± 0.12 | 0.48 |
| AST (U/L) | 31.24 ± 12.40 | 36.12 ± 13.12 | 0.10 | 18.36 ± 8.20 | 17.85 ± 4.67 | 0.83 |
| ALT (U/L) | 28.23 ± 14.18 | 23.18 ± 7.11 | 0.12 | 23.22 ± 6.85 | 25.21 ± 6.29 | 0.34 |
Data presented as mean ± SD. ∗P value <0.05 significant. P values calculated by independent Student's t test. PCOS: polycystic ovary syndrome, BMI: body mass index, SBP: systolic blood pressure, DBP: diastolic blood pressure, men: menarche, FG score: Ferriman–Gallwey score, LH: luteinizing hormone, FSH: follicle-stimulating hormone, TT: total testosterone, PRL: prolactin, TSH: thyroid-stimulating hormone, SHBG: sex hormone-binding globin, andro: androstenedione, DHEAS: dehydroepiandrosterone sulfate, Glu F: glucose fasting, CHOL: cholesterol, TG: triglycerides, HOMA: IR homeostasis model assessment-estimated insulin resistance, QUICKI: quantitative insulin sensitivity check index, FAI: free androgen index, UA: uric acid, Cre: creatinine, AST: aspartate aminotransferase, and ALT: alanine aminotransferase.