Figure 3.

Effects of sRAGE on pyroptosis in the myocardium following myocardial ischemia-reperfusion injury. (a) Representative immunohistochemical image of pyroptosis-associated proteins in myocardium, including NLRP3, caspase-1, GSDMD, IL-1β, and IL-18. The target protein is shown in brown, indicating pyroptosis-positive cardiomyocyte. The scale bar is 10 μm. (b) Quantitative statistics of immunohistochemical images is shown above. Data are expressed as the mean ± SEM (n ≥ 6 mice per group). ^∗p < 0.05; ^∗∗p < 0.01; ^∗∗∗p < 0.001; ns: no significance.