Table 1.
Clinical characteristics at baseline
| ALL | Control | Febuxostat | P value | |
|---|---|---|---|---|
| Number | 65 | 34 | 31 | |
| Clinical background | ||||
| Age, year | 71 [63,77] | 71 [63,77] | 71 [63,77] | 1.000 |
| Male, % | 80 (52) | 88 (30) | 71 (22) | 0.082 |
| Body mass index | 25.1 [22.2, 26.9] | 25.6 [22.9, 27.4] | 24.7 [22.1, 26.4] | 0.482 |
| Systolic BP, mmHg | 128 [118, 133] | 128 [120, 132] | 126 [115, 133] | 0.818 |
| Diastolic BP, mmHg | 72 [66,80] | 77 [68,80] | 72 [65,79] | 0.252 |
| Heart rate, bpm | 62 [58,72] | 63 [56,71] | 62 [59,72] | 0.555 |
| Clinical history | ||||
| Smoker, %, (n) | 55.4 (36) | 64.7 (22) | 45.2 (14) | 0.113 |
| Hypertension, %, (n) | 90.8 (59) | 88.2 (30) | 93.5 (29) | 0.460 |
| Diabetes mellitus, %, (n) | 41.5 (27) | 38.2 (13) | 45.2 (14) | 0.571 |
| Dyslipidemia, %, (n) | 63.1 (41) | 55.9 (19) | 71.0 (22) | 0.208 |
| Myocardial infarction, %, (n) | 13.8 (9) | 8.8 (3) | 19.4 (6) | 0.220 |
| PCI, %, (n) | 24.6 (16) | 17.6 (6) | 32.3 (10) | 0.172 |
| CABG, %, (n) | 6.2 (4) | 5.9 (2) | 6.5 (2) | 0.924 |
| Stroke, %, (n) | 4.6 (3) | 5.9 (2) | 3.2 (1) | 0.610 |
| Heart failure, %, (n) | 16.9 (11) | 8.8 (3) | 25.8 (8) | 0.068 |
| Medications | ||||
| ARB %, (n) | 61.5 (40) | 58.8 (20) | 64.5 (20) | 0.638 |
| ACEI %, (n) | 12.8 (8) | 11.8 (4) | 12.9 (4) | 0.889 |
| Beta blocker %, (n) | 44.6 (29) | 45.1 (15) | 45.2 (14) | 0.933 |
| Diuretic %, (n) | 33.8 (22) | 32.4 (11) | 35.5 (11) | 0.790 |
| Statin %, (n) | 47.7 (31) | 44.1 (15) | 51.6 (16) | 0.610 |
| Anti-platelet %, (n) | 47.7 (31) | 50.0 (17) | 45.2 (14) | 0.696 |
| Aspirin %, (n) | 41.5 (27) | 38.2 (13) | 45.2 (14) | 0.571 |
| Laboratory Data | ||||
| Total cholesterol, mmol/L | 4.56 [4.01, 5.25] | 4.55 [4.16, 5.25] | 4.58 [3.98, 5.31] | 0.968 |
| eGFR, mL/min/1.73m2 | 57.5 [47.0, 66.8] | 60.1 [53.2, 68.9] | 48.4 [42.5, 59.7] | 0.020 |
| Uric acid, mg/dL | 7.65 [7.10, 8.28] | 7.50 [7.10, 7.90] | 8.10 [7.35, 8.70] | 0.031 |
| NT-proBNP, pg/mL | 99.5 [33.3, 314.1] | 98.7 [33.3, 222.4] | 100.4 [37.3, 361.4] | 0.624 |
| Troponin I, pg/mL | 5.15 [3.20, 9.70] | 5.10 [3.30, 8.00] | 5.30 [3.15, 10.55] | 0.867 |
BP blood pressure, PCI percutaneous coronary intervention, ACEi angiotensin-converting-enzyme inhibitor, ARB angiotensin II receptor blocker, eGFR estimate glomerular filtration rate, NT-proBNP N-terminal-pro brain natriuretic peptide.
Data are presented as the number of patients (percentage), mean ± SD or median (interquartile range).