Table 2.
Studies addressing a possible genetic linkage between chronic skin inflammatory diseases and depression and/or anxiety.
| Authors (year of publication) | Study population | Control population | Psychopathological evaluation | Studied genes | Conclusions |
|---|---|---|---|---|---|
| Mossner et al. (2009) | 309 Ps patients (127 F and 182 M), mean age 46.0 ± 14.3 years; 140 patients with Ps positive family history. | 315 healthy unrelated subjects without personal or family history of Ps (146 F and 169 M), mean age 35.6 ± 12.1 years. | HAM-D performed only in a subgroup of 137 patients (aged 18–60 years) with mild/severe depression (HAM-D > 8). | Promoter of the gene encoding SERT (5-HTTLPR) | No significant difference in genotype distribution and allele frequencies and HAM-D score in Ps patients (n = 137) carrying different 5-HTTLPR genotypes. |
| Sobolev et al. (2019) | 88 Ps patients, selected according to ICD-10 criteria. | 365 healthy subjects. | Clinical diagnosis. | DBH, CCKAR, CCKBR, and COMT | Polygenic analysis
revealed two genotypes associated with Ps: 1. A combination of COMT heterozygote (rs4680:GA) and a deletion in DBH gene (Ins/Del 19:D); 2. COMT heterozygote (rs4680:GA). |
| de Mel et
al. (2012) |
33 patients (26 F and 7 M)
with a history of AD and anxiety, mean age 39.6 ± 12.3 years; AD diagnosed according to Hanifin and Rajka criteria. |
33 healthy subjects (primarily staff personnel and students), mean age 40.6 ± 12.2 years. | KSP questionnaire. | Short and long alleles of 5-HTTLPR | All AD patients with high anxiety traits carried the short variant of 5-HT transporter intron 2 polymorphism. |
| Kaga et
al. (2014) |
52 AD patients (30 M and
22 F); AD severity quantified by SCORAD Index. |
163 healthy volunteers (89 M and 74 F). | STAI. | TSPO (18 kDa) gene | In AD patients, lymphocyte
genomic analysis revealed an SNP of the human TSPO gene at exon 4
(485G>A); AD patients showed lower frequencies of GG and higher frequencies of GA. |
Abbreviations: F, female; M, male; HAM-D, Hamilton Rating Scale for Depression; SERT, serotonin transporter; 5-HTTLPR, serotonin-transporter-linked promoter region; ICD-10, International Classification of Diseases, Tenth Revision; DBH, dopamine beta-hydroxylase; CCKAR, cholecystokinin A receptor; CCKBR, cholecystokinin-B receptor; COMT, catechol-O-methyltransferase; KSP, Karolinska Scales of Personality; STAI, State-Trait Anxiety Inventory; SCORAD, SCORing Atopic Dermatitis; TSPO, translocator protein.