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Tumor budding as assessed by large sections. (A) Example of a whole slide image. (B) Magnified high-power field (HPF, ×10) area of (A) at the tumor front. (C) Magnified HPF (×10) area of (A) at the tumor front. (D) Magnified HPF (×10) area of (A) in the tumor center. (E) Magnified HPF (×100) area of (B). The black line delineates the tumor invasive front, and the red marks and yellow arrows indicate the tumor budding.
