Table 3.

Results of the univariate analysis between tumor budding and overall survival.

Variable	Statistics	HR (95% CI)	p-value
TB location, n (%)
No	58 (44.62)	1.0
PTB	10 (7.69)	2.37 (1.08–5.19)	0.03
ITB	11 (8.46)	1.57 (0.69–3.60)	0.28
TTB	51 (39.23)	2.02 (1.25–3.28)	0.004
PTB count, n (median, range)	0 (0–43)	1.03 (1.01–1.05)	0.01
PTB, n (%)
No	69 (53.08)	1.0
Yes	61 (46.92)	1.93 (1.25–2.99)	0.003
PTB, n (%)
<5	74 (56.92)	1.0
≥5	56 (43.08)	1.95 (1.26–3.02)	0.003
PTB, n (%)
<10	97 (74.62)	1.0
≥10	33 (25.38)	1.85 (1.15–2.97)	0.01
ITB count, n (median, range)	0 (0–41)	1.03 (1.01–1.05)	0.01
ITB, n (%)
No	68 (52.31)	1.0
Yes	62 (47.69)	1.69 (1.09–2.62)	0.02
ITB, n (%)
<5	78 (60.00)	1.0
≥5	52 (40.00)	1.73 (1.12–2.69)	0.01
ITB, n (%)
<10	97 (74.62)	1.0
≥10	33 (25.38)	2.00 (1.24–3.22)	0.005
TTB count, n (median, range)	5.5 (0–72)	1.02 (1.01–1.03)	0.005
TTB, n (%)
No	58 (44.62)	1.0
Yes	72 (55.38)	1.99 (1.26–3.13)	0.003
TTB, n (%)
<5	65 (50.00)	1.0
≥5	65 (50.00)	1.89 (1.21–2.94)	0.005
TTB, n (%)
<10	70 (53.85)	1.0
≥10	60 (46.15)	1.82 (1.17–2.81)	0.007
TB score	0.49 (0.00-1.08)	2.71 (1.48–4.96)	0.0012
TB score, n (%)
TB score-low group	84 (64.62)	1.0
TB score-high group	46 (35.38)	2.28 (1.46–3.54)	0.0003

HR, hazard ratio; CI, confidence interval; TB, tumor budding; PTB, peritumoral budding; ITB, intratumoral budding; TTB, total tumor budding (PTB+ITB).