Table 4.
Relationship between the budding and overall survival in different models.
| Variable | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
| TB location | ||||||
| No | 1.0 | 1.0 | 1.0 | |||
| PTB | 2.37 (1.08–5.19) | 0.03 | 2.30 (1.02–5.18) | 0.04 | 2.39 (1.05–5.44) | 0.04 |
| ITB | 1.57 (0.69–3.60) | 0.28 | 1.41 (0.61–3.23) | 0.42 | 1.28 (0.55–2.96) | 0.57 |
| TTB | 2.02 (1.25–3.28) | 0.004 | 1.92 (1.17–3.15) | 0.01 | 1.78 (1.09–2.92) | 0.02 |
| PTB count | 1.03 (1.01–1.05) | 0.014 | 1.03 (1.01–1.05) | 0.009 | 1.02 (1.00–1.05) | 0.03 |
| ITB count | 1.03 (1.01–1.05) | 0.008 | 1.03 (1.01–1.05) | 0.010 | 1.02 (1.00–1.04) | 0.06 |
| TTB count | 1.02 (1.01–1.03) | 0.005 | 1.02 (1.01–1.03) | 0.005 | 1.01 (1.00–1.02) | 0.03 |
| TB score | 2.71 (1.48–4.96) | 0.001 | 2.64 (1.40–4.95) | 0.003 | 2.35 (1.27–4.33) | 0.006 |
| TB score | ||||||
| TB score-low group | 1.0 | 1.0 | 1.0 | |||
| TB score-high group | 2.28 (1.46–3.54) | 0.0002 | 2.15 (1.37–3.38) | 0.0009 | 2.06 (1.32–3.22) | 0.0015 |
Model 1: adjusted for other covariates; model 2: adjusted for age, sex, and body mass index; model 3: further adjusted for location, T category, N category, and peripancreatic fat infiltration.
HR, hazard ratio; CI, confidence interval; TB, tumor budding; PTB, peritumoral budding; ITB, intratumoral budding; TTB, total tumor budding (PTB+ITB).