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. 2021 Dec 13;4:1390. doi: 10.1038/s42003-021-02919-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Analysis of four HB PDX by TEM at different magnifications. White dotted-line frame: Region-of-interest corresponding to immediately higher magnification. bc, blood capillary; bi, bile canaliculus-like structure; EC, endothelial cells; MA, macrophage; lv, lipid vesicles; mb; plasma membrane; mi, mitochondrion; n, nucleus; ni, nuclear invagination; nl, nucleolus; LY, lymphocyte; RC, red cells; TC, tumour cell. b Top panels: SBF-SEM stacks from two samples. Bottom panels: Extracted images of orthogonal plane from different faces of reconstructed volume (XY, YZ, XZ), whose positions are displayed on orthoslice view positions inside stack. Scale bar = 10 µm.